Meta-analysis of il12b polymorphisms (rs3212227, rs6887695) susceptibility genes for psoriasis/psa interleukin 12 (il-12) is a key regulator of the polarisation of immune our meta-analysis demonstrated the association of alleles of rs3212227 (c) and rs7530511 (c) with psoriasis/psa and. Likewise, effective management of psoriasis is linked to suppression of il-17 signaling (28,29), and genetic findings from genome-wide association studies have implicated genes that are more strongly involved in il-23/il-17 signaling than those for il-12 (5,30. While the p40 protein encoded by the il12b gene is a component of both il-12 and il-23, physiologic studies in psoriasis, crohn's disease, and mouse models of colitis have identified il-23 as the. The il-12 p40 subunit, il12b, and one of the il-23 receptor subunits, il23r, have been replicated in us and european populations and overlap with risk of study of psoriasis that yielded an association between psoriasis and cytokines and cytokine receptors relevant to.
Il-12 p40, which is encoded by il-12b gene, is known as a component of the bioactive cytokines il-12 and il-23 28 in this meta-analysis, the results indicated that carriers of genotype cc or allele c of il-12b rs3212227 had a lower risk of psoriasis. An interleukin 12 b single nucleotide polymorphism increases il-12p40 production and is associated with increased disease susceptibility in patients with relapsing-remitting multiple sclerosis. We performed a multi-tiered, case-control association study of psoriasis in three independent, white north american sample sets (1446 cases/1432 controls) with 25,215 gene-centric snps and found a highly significant association with an il12b 3’utr snp (rs3212227) confirming the results of a small japanese study. Il-12, the first identified member of the il-12 cytokine family, is a key th1 cytokine involved in initiating and mediating th1 immune responses, which act as the bridge connecting early non-specific with secondary antigen-specific immune responses.
Table 2 from: genetic variants of the il-23r pathway: association with psoriatic arthritis and psoriasis vulgaris, but no specific risk factor for arthritis. To investigate the association of three common functional gene polymorphisms, namely tnf-308 g/a (rs1800629), il12b (encoding the p40 subunit of il-12/23) +1188 a/c (rs3212227), and ifng +874 t/a (rs2430561) with psoriasis development and severity in serbian patients. Reviews specific targeting of interleukin-23p19 as effective treatment for psoriasis adriane a levin, ba,a,b and alice b gottlieb, md, phdb,c boston, massachusetts interleukin (il)-23 is a heterodimeric cytokine composed of a distinct p19 subunit and a p40 subunit. Background: psoriasis is a t-cell mediated chronic systemic inflammatory skin disease emerging evidences suggest the interleukin (il)-12b and il-23r genes encoding the. Psoriasis is a t-cell mediated chronic systemic inflammatory skin disease emerging evidences suggest the interleukin (il)-12b and il-23r genes encoding the common p40 subunit of il-12 and il-23 are the key cytokines in t-helper (th)1 and th17 differentiation and function.
Il-12 in psoriasis7,8 the single-nucleotide polymorphism (snp), rs3212227, is located in the il-12b gene, which encodes il-12 p40 association between il-12b rs3212227 polymorphism and risk of. Background psoriasis is a t-cell mediated chronic systemic inflammatory skin disease emerging evidences suggest the interleukin (il)-12b and il-23r genes encoding the common p40 subunit of il-12 and il-23 are the key cytokines in t-helper (th)1 and th17 differentiation and function. Psoriasis is a complex genetic disease, which has previously been associated with numerous single nucleotide polymorphisms (snps) that are implicated in various processes, including skin barrier functions and in the regulation of inflammatory and immune responses. Our study confirms the association of il-12b with psoriasis and reveals that the g allele of rs6887695 of il-12b and the a-a haplotype of rs11465817-rs1343152 of il-23r confer an increased risk of psoriasis in the chinese han population.
Association study of il-12b polymorphisms susceptibility with ankylosing spondylitis in mainland han population: 2015: (rs3212227, rs6887695) with psoriasis and psoriatic arthritis 2013: 1: interleukin-12: clinical usage and molecular markers of cancer susceptibility. Abstract—genome-wide association studies of psoriasis identified interleukin (il)-12b and il-23r as significantly both il-12 and il-23 have been associated with the the rs6887695 and rs3212227 snps in il 12b as well as the rs11209026 and rs7530511. Investigation of association of the il12b and il23r genes with psoriatic arthritis код для вставки. [pmid 23297015] meta-analysis of il12b polymorphisms (rs3212227, rs6887695) with psoriasis and psoriatic arthritis [ pmid 23564024 ] association of il-12b gene rs6887695 polymorphism with hereditary susceptibility and clinical characterization of psoriasis vulgaris in the chinese han population.
Interleukin (il)-12 is one of the key cytokines in immune regulation and is overexpressed in psoriasis the aim of this study was to update the meta-analysis for the association between il-12 p40 gene (il-12b) rs3212227 polymorphism and risk of psoriasismethodswe performed a literature search from inception to december 2014. Role of il-12 and il-23 in psoriasis in recent years the roles of cytokines il-12 and il-23 in psoriasis have become increasingly more clear (fitch et al043 0 mounting evidence suggests that il-23 may have a more critical role than il-12 in the development of psoriasis. In this study, we identified for the first time a significant association of il-12b genes snps rs3212227 and rs6887695 with an increased risk of ra in a chinese han population, highlighting the importance of population-specific association, consistent with previous findings 34. In addition, il-12 p40 is a master switch in psoriasis and is associated with the formation of il-23 and biological activities of il-12 the mrna and protein expressions of il-12 p40 are increased in the psoriatic skin, and could be changed by the different genotypes and alleles of il-12b rs3212227.
[pmid 23297015] meta-analysis of il12b polymorphisms (rs3212227, rs6887695) with psoriasis and psoriatic arthritis [pmid 22740240] associations association of il-12a and il-12b polymorphisms with alzheimer's disease predictive role of cytokines il-10, il-12 and tnf-α gene polymorphisms for the development of osteonecrosis of the. Prior to examining the functional association between circulating il-12 levels and rs3212227 variants, il-12 levels were log-transformed towards normality and. View this abstract online a large-scale genetic association study confirms il12b and leads to the identification of il23r as psoriasis-risk genes.